Pujol-Gimenez, J, de Heredia, FP, Angel Idoate, M, Airley, R, Pilar Lostao, M and Evans, AR (2015) Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report. Journal of Cancer, 6 (2). pp. 139-143. ISSN 1837-9664

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Abstract

Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells.

Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer
cell lines and a tumour spheroid model.

Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which
is characterised by anaerobic metabolism.
Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer
cells and therefore, its potential as a novel therapeutic target for cancer treatment.

Item Type:	Article
Uncontrolled Keywords:	Science & Technology; Life Sciences & Biomedicine; Oncology; GLUT12; Cancer cell lines; Spheroid; Immunohistochemistry; Glycolytic metabolism; FACILITATIVE GLUCOSE TRANSPORTERS; HUMAN PLACENTA; TUMOR HYPOXIA; EXPRESSION; P53; LOCALIZATION; TISSUES; AGENTS; CELLS
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Ivyspring International Publisher
Related URLs:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352000200006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=7f77ca1697db64ccb27a8011c7ced90d
Date Deposited:	21 May 2015 10:28
Last Modified:	04 Sep 2021 14:42
DOI or ID number:	10.7150/jca.10429
URI:	https://researchonline.ljmu.ac.uk/id/eprint/425

Available Versions of this Item

• Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report. (deposited 30 Jan 2015 11:02)
  • Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report. (deposited 21 May 2015 10:28) [Currently Displayed]
    • Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report. (deposited 13 Nov 2015 13:52)

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