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Casey, DR, Charalambous, K, Gee, A, Law, RV and Ces, O (2014) Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature. Interface, 11 (94).
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Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature..pdf - Published Version Download (784kB) | Preview |
Abstract
Small-molecule amphiphilic species such as many drug molecules frequently exhibit low-to-negligible aqueous solubility, and generally have no identified transport proteins assisting their distribution, yet are able to rapidly penetrate significant distances into patient tissue and even cross the blood-brain barrier. Previous work has identified a mechanism of translocation driven by acid-catalysed lipid hydrolysis of biological membranes, a process which is catalysed by the presence of cationic amphiphilic drug molecules. In this study, the interactions of raclopride, a model amphiphilic drug, were investigated with mixtures of biologically relevant lipids across a range of compositions, revealing the influence of the chain-melting temperature of the lipids upon the rate of acyl hydrolysis.
| Item Type: | Article |
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| Uncontrolled Keywords: | MD Multidisciplinary |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Civil Engineering & Built Environment |
| Publisher: | Royal Society Publishing |
| Related URLs: | |
| Date Deposited: | 06 Mar 2015 10:44 |
| Last Modified: | 04 Sep 2021 14:38 |
| DOI or ID number: | 10.1098/rsif.2013.1062 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/535 |
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