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Zhu, J-Y, Zhang, C-Y, Dai, J-J, Rahman, K and Zhang, H (2017) Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida. Natural Product Research. ISSN 1478-6419
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Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida..pdf - Accepted Version Download (381kB) | Preview |
Abstract
Chemical investigation of the Jatropha multifida has led to the isolation of nine diterpenoids (1-9), including a new jatromulone A, four podocarpane diterpenoids (2-5), two lathyrane-type diterpenoids (6 and 7) and two dinorditerpenoids (8 and 9). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1 were determined by CD analysis. All of the diterpenoids were screened for inhibitory activity against thioredoxin reductase (TrxR), which is a potential target for cancer chemotherapy with redox balance and antioxidant functions. Compounds 6 and 7 exhibited stronger activity (IC50: 23.4 and 10.6 μM, respectively) than the positive control, curcumin (IC50 = 25.0 μM). Compounds 2-9 were isolated from J. multifida for the first time.
| Item Type: | Article |
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| Additional Information: | “This is an Accepted Manuscript of an article published by Taylor & Francis in Natural Product Research on 10th March 2017, available online: http://www.tandfonline.com/10.1080/14786419.2017.1297441 |
| Uncontrolled Keywords: | MD Multidisciplinary |
| Subjects: | Q Science > QD Chemistry Q Science > QK Botany |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Taylor & Francis |
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| Date Deposited: | 24 Mar 2017 12:31 |
| Last Modified: | 04 Sep 2021 11:47 |
| DOI or ID number: | 10.1080/14786419.2017.1297441 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/6080 |
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