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The regulatory mechanism of fungal elicitor-induced secondary metabolite biosynthesis in medical plants.

Zhai, X, Jia, M, Chen, L, Zheng, C-J, Rahman, K, Han, T and Qin, L-P (2016) The regulatory mechanism of fungal elicitor-induced secondary metabolite biosynthesis in medical plants. Critical Reviews in Microbiology, 43 (2). pp. 238-261. ISSN 1040-841X

ManuscripFungalElicitor_Oct_15 2015-11-5.pdf - Accepted Version

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A wide range of external stress stimuli trigger plant cells to undergo complex network of reactions that ultimately lead to the synthesis and accumulation of secondary metabolites. Accumulation of such metabolites often occurs in plants subjected to stresses including various elicitors or signal molecules. Throughout evolution, endophytic fungi, an important constituent in the environment of medicinal plants, have known to form long-term stable and mutually beneficial symbiosis with medicinal plants. The endophytic fungal elicitor can rapidly and specifically induce the expression of specific genes in medicinal plants which can result in the activation of a series of specific secondary metabolic pathways resulting in the significant accumulation of active ingredients. Here we summarize the progress made on the mechanisms of fungal elicitor including elicitor signal recognition, signal transduction, gene expression and activation of the key enzymes and its application. This review provides guidance on studies which may be conducted to promote the efficient synthesis and accumulation of active ingredients by the endogenous fungal elicitor in medicinal plant cells, and provides new ideas and methods of studying the regulation of secondary metabolism in medicinal plants.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Critical Reviews in Microbiology on 10/12/2016, available online: http://www.tandfonline.com10.1080/1040841X.2016.1201041/
Uncontrolled Keywords: 0605 Microbiology, 1108 Medical Microbiology
Subjects: Q Science > QR Microbiology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
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Date Deposited: 11 Apr 2017 11:16
Last Modified: 04 Sep 2021 11:44
DOI or ID number: 10.1080/1040841X.2016.1201041
URI: https://researchonline.ljmu.ac.uk/id/eprint/6241
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