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Thow, ME, Summers, MJ, Summers, JJ, Saunders, NL and Vickers, JC (2017) Variations in the APOE allele or BDNF Val66Met polymorphism are not associated with changes in cognitive function following a tertiary education intervention in older adults: the Tasmanian Healthy Brain Project. Neurobiology of Aging. ISSN 0197-4580
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Thow et al (2017 accepted manuscript) Neurobiol of Aging.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (245kB) | Preview |
Abstract
The apolipoprotein (APOE) ε4 allele and the Met variant of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism are associated with reduced cognitive function in older adults. The aim of this study was to examine the independent and interactional effect of the APOE ε4 allele and BDNF Val66Met polymorphism on cognitive function in a cohort of healthy older adults who had undertaken further university level education. Multiple group latent growth curve modeling revealed no change in cognitive function over time in APOE ε4-carriers or in BDNF Met-carriers, nor in carriers of both APOE-ε4 and BDNF-Met alleles. Further, the results indicate that allelic variation in either APOE or BDNF does not modify the beneficial effects of a university-based education intervention on cognitive function over a 4-year period following the intervention.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1103 Clinical Sciences, 1109 Neurosciences |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Elsevier |
| Related URLs: | |
| Date Deposited: | 03 May 2017 11:51 |
| Last Modified: | 04 Sep 2021 03:59 |
| DOI or ID number: | 10.1016/j.neurobiolaging.2017.03.028 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/6356 |
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