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Gimenez, D, Mooney, CA, Dose, A, Sandford, G, Coxon, CR and Cobb, SL (2017) The Application of Perfluoroheteroaromatic Reagents in the Preparation of Modified Peptide Systems. Organic and Biomolecular Chemistry. ISSN 1477-0539
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The Application of Perfluoroheteroaromatic Reagents in the Preparation of Modified Peptide Systems.pdf - Accepted Version Download (1MB) | Preview |
Publisher URL: http://dx.doi.org/10.1039/C7OB00283A
Abstract
The perfluoroheteroaromatic reagent pentafluoropyridine has proved to be a highly reactive electrophile, undergoing SNAr arylation reactions in the presence of a range of nucleophilic peptide side chains (i.e. cysteine, tyrosine, serine and lysine) under mild conditions. Moreover, we have shown how one-step peptide-modification using perfluoroheteroaromatics can deliver enhanced proteolytic stability in pharmaceutically-relevant peptides such as oxytocin.
| Item Type: | Article |
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| Uncontrolled Keywords: | 0304 Medicinal And Biomolecular Chemistry, 0305 Organic Chemistry, 1115 Pharmacology And Pharmaceutical Sciences |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Royal society of Chemistry |
| Date Deposited: | 16 May 2017 09:41 |
| Last Modified: | 04 Sep 2021 11:35 |
| DOI or ID number: | 10.1039/C7OB00283A |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/6426 |
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