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Pugh, JN, Sage, S, Hutson, M, Doran, DA, Fleming, SC, Highton, J, Morton, JP and Close, GL (2017) Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner. European Journal of Applied Physiology. ISSN 1439-6327
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Abstract
PURPOSE: To examine the dose-response effects of acute glutamine supplementation on markers of gastrointestinal (GI) permeability, damage and, secondary, subjective symptoms of GI discomfort in response to running in the heat. METHODS: Ten recreationally active males completed a total of four exercise trials; a placebo trial and three glutamine trials at 0.25, 0.5 and 0.9 g kg(-1) of fat-free mass (FFM) consumed 2 h before exercise. Each exercise trial consisted of a 60-min treadmill run at 70% of [Formula: see text] in an environmental chamber set at 30 °C. GI permeability was measured using ratio of lactulose to rhamnose (L:R) in serum. Plasma glutamine and intestinal fatty acid binding protein (I-FABP) concentrations were determined pre and post exercise. Subjective GI symptoms were assessed 45 min and 24 h post-exercise. RESULTS: Relative to placebo, L:R was likely lower following 0.25 g kg(-1) (mean difference: - 0.023; ± 0.021) and 0.5 g kg(-1) (- 0.019; ± 0.019) and very likely following 0.9 g kg(- 1) (- 0.034; ± 0.024). GI symptoms were typically low and there was no effect of supplementation. DISCUSSION: Acute oral glutamine consumption attenuates GI permeability relative to placebo even at lower doses of 0.25 g kg(-1), although larger doses may be more effective. It remains unclear if this will lead to reductions in GI symptoms. Athletes competing in the heat may, therefore, benefit from acute glutamine supplementation prior to exercise in order to maintain gastrointestinal integrity.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1106 Human Movement And Sports Science |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Springer Verlag |
| Related URLs: | |
| Date Deposited: | 02 Nov 2017 10:30 |
| Last Modified: | 04 Sep 2021 11:03 |
| DOI or ID number: | 10.1007/s00421-017-3744-4 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/7465 |
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