Ehtezazi, T, Algellay, M, Islam, Y, Roberts, M, Dempster, NM and Sarker, SD (2017) The Application of 3D Printing in the Formulation of Multilayered Fast Dissolving Oral Films. Journal of Pharmaceutical Sciences, 107 (4). pp. 1076-1085. ISSN 0022-3549

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Abstract

Fast dissolving oral films (FDFs) provide an alternative approach to increase consumer acceptance by advantage of rapid dissolution and administration without water. Usually FDFs require taste-masking agents. However, inclusion of these excipients could make developing the formulation a challenging task. Hence, this work employed fused-deposition modelling three-dimensional (FDM 3D) printing to produce single-layered (SLFDFs), or multilayered (MLFDFs) films, with taste-masking layers being separated from drug layer. Filaments were prepared containing polyethylene oxide (PEO) with ibuprofen or paracetamol as model drugs at 60°C. Also filaments were produced containing polyvinyl alcohol (PVA) and paracetamol at 130°C. Furthermore, a filament was prepared containing PEO and strawberry powder for taste-masking layer. FDFs were printed at temperatures of 165°C (PEO) or 190ºC (PVA) with plain or mesh designs. HPLC and mass-spectroscopy analysis indicated active ingredient stability during film preparation process. SLFDFs had thicknesses as small as 197±21μm, and MLFDFs had thicknesses starting from 298±15μm. Depending on the formulation and design, mesh SLFDFs presented disintegration time as short as 42±7s, and this was 48±5s for mesh MLFDFs. SLFDFs showed drug content uniformity in the range of 106.0%-112.4%. In conclusion, this study provides proof-of-concept for the manufacturing of FDFs by using 3D printing.

Item Type:	Article
Uncontrolled Keywords:	1115 Pharmacology And Pharmaceutical Sciences
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Elsevier
Related URLs:	Author
Date Deposited:	14 Dec 2017 09:54
Last Modified:	04 Sep 2021 10:54
DOI or ID number:	10.1016/j.xphs.2017.11.019
URI:	https://researchonline.ljmu.ac.uk/id/eprint/7720

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