Wilding, CS (2017) Genetic diversity of the African malaria vector Anopheles gambiae. Nature, 552. pp. 96-100. ISSN 0028-0836

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Abstract

The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.

Item Type:	Article
Uncontrolled Keywords:	MD Multidisciplinary
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology > QR180 Immunology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Natural Sciences & Psychology (closed 31 Aug 19)
Publisher:	Nature Publishing Group
Related URLs:	http://dx.doi.org/10.1038/nature24995
Date Deposited:	05 Jan 2018 09:35
Last Modified:	04 Sep 2021 10:53
DOI or ID number:	10.1038/nature24995
URI:	https://researchonline.ljmu.ac.uk/id/eprint/7775

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