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Tang, AD, Bennett, W, Hadrill, C, Collins, J, Fulopova, B, Wills, K, Bindoff, A, Puri, R, Garry, MI, Hinder, MR, Summers, JJ, Rodger, J and Canty, AJ (2018) Low intensity transcranial magnetic stimulation modulates skilled motor learning in adult mice. Scientific Reports, 8. ISSN 2045-2322
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Tang et al. Scientific Reports 2018.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Repetitive transcranial magnetic stimulation (rTMS) is commonly used to modulate cortical plasticity in clinical and non-clinical populations. Clinically, rTMS is delivered to targeted regions of the cortex at high intensities (>1 T). We have previously shown that even at low intensities, rTMS induces structural and molecular plasticity in the rodent cortex. To determine whether low intensity rTMS (LI-rTMS) alters behavioural performance, daily intermittent theta burst LI-rTMS (120 mT) or sham was delivered as a priming or consolidating stimulus to mice completing 10 consecutive days of skilled reaching training. Relative to sham, priming LI-rTMS (before each training session), increased skill accuracy (~9%) but did not alter the rate of learning over time. In contrast, consolidating LI-rTMS (after each training session), resulted in a small increase in the rate of learning (an additional ~1.6% each day) but did not alter the daily skill accuracy. Changes in behaviour with LI-rTMS were not accompanied with long lasting changes in brain-derived neurotrophic factor (BDNF) expression or in the expression of plasticity markers at excitatory and inhibitory synapses for either priming or consolidation groups. These results suggest that LI-rTMS can alter specific aspects of skilled motor learning in a manner dependent on the timing of intervention.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Nature Publishing Group |
| Date Deposited: | 14 Mar 2018 10:02 |
| Last Modified: | 04 Sep 2021 02:53 |
| DOI or ID number: | 10.1038/s41598-018-22385-8 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/8283 |
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