Tools
Tools
Basar, N, Oridupa, OA, Ritchie, KJ, Nahar, L, Osman, NMM, Stafford, A, Kushiev, H, Kan, A and Sarker, SD (2015) Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells. PHYTOTHERAPY RESEARCH, 29 (6). pp. 944-948. ISSN 0951-418X
This is the latest version of this item.
|
Text
PTR14_1269_Glyc_Revised170115_Revised190215.pdf - Accepted Version Download (376kB) | Preview |
Abstract
Glycyrrhiza glabra L. (Fabaceae), commonly known as 'liquorice', is a well-known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, antiinflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and cardioprotective properties. While glycyrrhizin, a sweet-tasting triterpene saponin, is the principal bioactive compound, several bioactive flavonoids and isoflavonoids are also present in the roots of this plant. In the present study, the cytotoxicity of the methanol extracts of nine samples of the roots of G.-glabra, collected from various geographical origins, was assessed against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cell lines using the in vitro 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide cell toxicity/viability assay. Considerable variations in levels of cytotoxicity were observed among various samples of G.-glabra.
| Item Type: | Article |
|---|---|
| Additional Information: | This is the peer reviewed version of the following article: Basar, N, Oridupa, OA, Ritchie, KJ, Nahar, L, Osman, NMM, Stafford, A, Kushiev, H, Kan, A, and Sarker, SD (2015), Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells. Phytother. Res., 29, 944–948, which has been published in final form at http://dx.doi.org/10.1002/ptr.5329 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving |
| Uncontrolled Keywords: | 11 Medical And Health Sciences, 03 Chemical Sciences, 06 Biological Sciences |
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | WILEY-BLACKWELL |
| Related URLs: | |
| Date Deposited: | 09 Oct 2015 12:06 |
| Last Modified: | 04 Sep 2021 14:32 |
| DOI or ID number: | 10.1002/ptr.5329 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/830 |
Available Versions of this Item
-
Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells. (deposited 23 Mar 2015 14:08)
- Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells. (deposited 09 Oct 2015 12:06) [Currently Displayed]
 |
View Item |