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Impact of handgrip exercise intensity on brachial artery flow-mediated dilation.

Atkinson, CL, Carter, HH, Dawson, EA, Naylor, LH, Thijssen, DHJ and Green, DJ (2015) Impact of handgrip exercise intensity on brachial artery flow-mediated dilation. European Journal of Applied Physiology. ISSN 1439-6327


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PURPOSE: Previous studies that have examined the impact of exercise intensity on conduit artery endothelial function have involved large muscle group exercise which induces local and systemic effects. The aim of this study was to examine flow-mediated dilation (FMD) before and after incremental intensities of handgrip exercise (HE), to assess the role of local factors such as blood flow and shear rate on post-exercise brachial artery function. METHODS: Eleven healthy men attended the laboratory on three occasions. Subjects undertook 30 min of handgrip exercise at three intensities (5, 10 or 15 % MVC). Brachial artery FMD, shear and blood flow patterns were examined before, immediately after and 60 min post exercise. RESULTS: Handgrip exercise increased mean and antegrade shear rate (SR) and blood flow (BF) and reduced retrograde SR and BF (all P < 0.01). Exercise intensity was associated with a dose-dependent increase in both mean and antegrade BF and SR (interaction, P < 0.01). Post-hoc tests revealed that, whilst handgrip exercise did not immediately induce post-exercise changes, FMD was significantly higher 60 min post-exercise following the highest exercise intensity (5.9 ± 2.8-10.4 ± 5.8 %, P = 0.01). CONCLUSIONS: Handgrip exercise leads to intensity-and time-dependent changes in conduit artery function, possibly mediated by local increases in shear, with improvement in function evident at 1 h post-exercise when performed at a higher intensity.

Item Type: Article
Additional Information: The final publication is available at Springer via: http://dx.doi.org/10.1007/s00421-015-3157-1
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Springer Verlag
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Date Deposited: 07 Apr 2015 10:43
Last Modified: 04 Sep 2021 14:32
DOI or ID number: http://link.springer.com/article/10.1007%2Fs00421-015-3157-1
URI: https://researchonline.ljmu.ac.uk/id/eprint/851
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