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Distinct Effects of Blood Flow and Temperature on Cutaneous Microvascular Adaptation

Carter, HH, Spence, AL, Atkinson, CL, Pugh, CJA, Cable, NT, Thijssen, DHJ, Naylor, LH and Green, DJ (2014) Distinct Effects of Blood Flow and Temperature on Cutaneous Microvascular Adaptation. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46 (11). pp. 2113-2121. ISSN 1530-0315


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Aims: We performed two experiments to determine whether cutaneous microvascular adaptations in response to repeated core temperature elevation are mediated by increases in skin temperature, and/or, skin blood flow. Methods: Healthy subjects participated for 8-weeks in thrice-weekly bouts of 30mins lower limb heating (40°C). In Study 1, both forearms were “clamped” at basal skin temperature throughout each heating bout (n=9). Study 2 involved identical lower limb heating, with the forearms under ambient conditions (unclamped, n=10). In both studies, a cuff was inflated around one forearm during the heating bouts to assess the contribution of skin blood flow and temperature responses. We assessed forearm skin blood flow responses to both lower limb (systemic reflex) heating, and to local heating of the forearm skin, pre and post intervention. Results: Acutely, lower limb heating increased core temperature (Study 1: +0.63±0.15°C, Study 2: +0.69±0.19°C, P<0.001) and forearm skin blood flow (Study 1: 10±3 vs 125±44, Study 2: 16±9 vs 136±41 PU, P<0.001), with skin responses significantly attenuated in the cuffed forearm (P<0.01). Skin blood flow responses to local heating decreased in Study 1 (clamped forearms, week 0vs8: 1.46±0.52 vs 0.99±0.44 CVC, P<0.05), whereas increases occurred in Study 2 (unclamped; week 0vs8: 1.89±0.57 vs 2.27±0.52 CVC, P<0.05). Cuff placement abolished local adaptations in both studies. Conclusion: Our results indicate that repeated increases in skin blood flow and skin temperature result in increased skin flux responses to local heating, whereas repeated increases in skin blood flow in the absence of change in skin temperature induced the opposite response. Repeated increases in core temperature induce intrinsic microvascular changes, the nature of which are dependent upon both skin blood flow and skin temperature.

Item Type: Article
Additional Information: This is a non-final version of an article published in final form: Carter, H. H., Spence, A. L., Atkinson, C. L, Pugh, C. J. A., Cable, N. T., Thijssen, D. H. J., Naylor, L. H., Green, D. J.(2014)MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. 46 (11) 2113-2121. http://dx.doi.org/10.1249/MSS.0000000000000349
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American College of Sports Medicine (ACSM)
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Date Deposited: 07 Apr 2015 10:20
Last Modified: 04 Sep 2021 14:32
DOI or ID number: 10.1249/MSS.0000000000000349
URI: https://researchonline.ljmu.ac.uk/id/eprint/853
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