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rEHR: An R package for manipulating and analysing Electronic Health Record data

Springate, DA, Parisi, R, Olier, I, Reeves, D and Kontopantelis, E (2017) rEHR: An R package for manipulating and analysing Electronic Health Record data. PLoS One, 12 (2). ISSN 1932-6203

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Research with structured Electronic Health Records (EHRs) is expanding as data becomes more accessible; analytic methods advance; and the scientific validity of such studies is increasingly accepted. However, data science methodology to enable the rapid searching/extraction, cleaning and analysis of these large, often complex, datasets is less well developed. In addition, commonly used software is inadequate, resulting in bottlenecks in research workflows and in obstacles to increased transparency and reproducibility of the research. Preparing a research-ready dataset from EHRs is a complex and time consuming task requiring substantial data science skills, even for simple designs. In addition, certain aspects of the workflow are computationally intensive, for example extraction of longitudinal data and matching controls to a large cohort, which may take days or even weeks to run using standard software. The rEHR package simplifies and accelerates the process of extracting ready-for-analysis datasets from EHR databases. It has a simple import function to a database backend that greatly accelerates data access times. A set of generic query functions allow users to extract data efficiently without needing detailed knowledge of SQL queries. Longitudinal data extractions can also be made in a single command, making use of parallel processing. The package also contains functions for cutting data by time-varying covariates, matching controls to cases, unit conversion and construction of clinical code lists. There are also functions to synthesise dummy EHR. The package has been tested with one for the largest primary care EHRs, the Clinical Practice Research Datalink (CPRD), but allows for a common interface to other EHRs. This simplified and accelerated work flow for EHR data extraction results in simpler, cleaner scripts that are more easily debugged, shared and reproduced.

Item Type: Article
Uncontrolled Keywords: MD Multidisciplinary
Subjects: H Social Sciences > HA Statistics
R Medicine > R Medicine (General)
Divisions: Applied Mathematics (merged with Comp Sci 10 Aug 20)
Publisher: Public Library of Science
Related URLs:
Date Deposited: 27 Sep 2018 10:44
Last Modified: 04 Sep 2021 02:25
DOI or ID number: 10.1371/journal.pone.0171784
URI: https://researchonline.ljmu.ac.uk/id/eprint/9342
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