Tools
Tools
Fergani, C, Leon, S, Padilla, SL, Verstegen, AMJ, Palmiter, RD and Navarro, VM (2018) NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice. eLife, 7. ISSN 2050-084X
|
Text
elife-40476-v1.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Neurokinin B (NKB) signaling is critical for reproduction in all studied species. The existing consensus is that NKB induces GnRH release via kisspeptin (Kiss1) stimulation in the arcuate nucleus. However, the stimulatory action of NKB is dependent on circulating estrogen (E2) levels, without which, NKB inhibits luteinizing hormone (LH) release. Importantly, the evidence supporting the kisspeptin-dependent role of NKB, derives from models of persistent hypogonadal state [e.g. Kiss1r knock-out (KO) mice], with reduced E2 levels. Here, we demonstrate that in the presence of E2, NKB signaling induces LH release in a kisspeptin-independent manner through the activation of NK3R (NKB receptor) neurons in the posterodorsal medial amygdala (MePD). Importantly, we show that chemogenetic activation of MePD Kiss1 neurons induces LH release, however, the stimulatory action of NKB in this area is Kiss1 neuron-independent. These results document the existence of two independent neuronal circuitries within the MePD that regulate reproductive function in females.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Science & Technology; Life Sciences & Biomedicine; Biology; Life Sciences & Biomedicine - Other Topics; LUTEINIZING-HORMONE SECRETION; NEUROKININ-B; ARCUATE NUCLEUS; KISS1 NEURONS; RECEPTORS; RAT; PROJECTIONS; ACTIVATION; JUVENILE; SYSTEM |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Natural Sciences & Psychology (closed 31 Aug 19) |
| Publisher: | eLife Sciences Publications Ltd |
| Related URLs: | |
| Date Deposited: | 29 Jan 2019 12:19 |
| Last Modified: | 04 Sep 2021 09:46 |
| DOI or ID number: | 10.7554/eLife.40476 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/10061 |
 |
View Item |