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Chudzicka-Ormaniec, P, Macios, M, Koper, M, Weedall, GD, Caddick, MX, Weglenski, P and Dzikowska, A (2019) The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans. FEMS Microbiology Letters, 366 (6). ISSN 1574-6968
Full text not available from this repository. Please see publisher or open access link below:Abstract
In Aspergillus nidulans, nitrogen and carbon metabolism are under the control of wide-domain regulatory systems, including nitrogen metabolite repression, carbon catabolite repression and the nutrient starvation response. Transcriptomic analysis of the wild type strain grown under different combinations of carbon and nitrogen regimes was performed, to identify differentially regulated genes. Carbon metabolism predominates as the most important regulatory signal but for many genes, both carbon and nitrogen metabolisms coordinate regulation. To identify mechanisms coordinating nitrogen and carbon metabolism, we tested the role of AreB, previously identified as a regulator of genes involved in nitrogen metabolism. Deletion of areB has significant phenotypic effects on the utilization of specific carbon sources, confirming its role in the regulation of carbon metabolism. AreB was shown to regulate the expression of areA, tamA, creA, xprG and cpcA regulatory genes suggesting areB has a range of indirect, regulatory effects. Different isoforms of AreB are produced as a result of differential splicing and use of two promoters. These are differentially regulated by carbon and nitrogen conditions. These are likely to be functionally distinct and thus contributing to the modulation of AreB activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 06 Biological Sciences, 11 Medical and Health Sciences, 07 Agricultural and Veterinary Sciences |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology |
| Divisions: | Natural Sciences & Psychology (closed 31 Aug 19) |
| Publisher: | Oxford University Press (OUP) |
| Related URLs: | |
| Date Deposited: | 14 May 2019 10:48 |
| Last Modified: | 03 Sep 2021 21:10 |
| DOI or ID number: | 10.1093/femsle/fnz066 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/10688 |
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