Nahar, L, Guo, M and Sarker, SD (2019) A review on the latest advances in extraction and analysis of artemisinin. Phytochemical Analysis. ISSN 0958-0344

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Abstract

Introduction: Artemisinin (1), a well-known natural antimalarial drug, is a sesquiterpene lactone that contains a unique peroxide bridge. Since its discovery, the amount of research into the analysis of artemisinin has increased considerably, and it has been further intensified since the Noble Prize win by Tu Youyou in the year 2015 for the discovery of artemisinin.
Objective: To review published literature on the extraction and analysis of artemisinin, published during 2017-present, and to present an appraisal of those methods.
Methodology: Extensive literature search was carried out which involved, but not limited to, the use of, various databases, like Web of Knowledge, PubMed and Google Scholar, and relevant published materials including published books. The keywords used, in various combinations, with artemisinin being present in all combinations, in the search were artemisinin, Artemisia annua, analysis, extraction, quantitative, qualitative and quality control.
Results: During the period covered in this review, there are several methods of analysis of artemisinin have been reported, the most of which were LC-based methods. However, the use of new methods like near infrared analysis, fluorometirc analysis and molecular imprinting, and a significant increase in the use of computational tools have been observed. Mainly several methods involving supercritical fluid extraction and ultrasound-assisted extraction of artemisinin have dominated the extraction area.
Conclusions: Newer analytical tools, as well as improved protocols for the known analytical tools, for qualitative and quantitative determination of artemisinin (1), have been made available by various researchers during the period covered by this review. Supercritical fluid extraction and ultrasound-assisted extraction are still the methods of choice for extraction of artemisinin.

Item Type:	Article
Additional Information:	This is the peer reviewed version of the following article: Nahar, L, Guo, M, Sarker, SD. A review on the latest advances in extraction and analysis of artemisinin. Phytochemical Analysis. 2019; 1– 10. https://doi.org/10.1002/pca.2873, which has been published in final form at https://dx.doi.org/10.1002/pca.2873. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Uncontrolled Keywords:	03 Chemical Sciences, 11 Medical and Health Sciences, 06 Biological Sciences
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Wiley
Date Deposited:	11 Jun 2019 10:21
Last Modified:	04 Sep 2021 09:18
DOI or ID number:	10.1002/pca.2873
URI:	https://researchonline.ljmu.ac.uk/id/eprint/10865

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