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Afroz, M, Zihad, SMNK, Uddin, SJ, Rouf, R, Rahman, MS, Islam, MT, Khan, IN, Ali, ES, Aziz, S, Shilpi, JA, Nahar, L and Sarker, SD (2019) A systematic review on antioxidant and anti-inflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of anti-inflammatory activity by chemical profiling and molecular docking. Phytotherapy Research, 33 (10). pp. 2585-2608. ISSN 1099-1573
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A systematic review on antioxidant and anti-inflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of anti-inflammatory activity by chemical profiling andmolecular docking.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Traditionally sesame oil has been used as a popular food and medicine. The review aims to summarize the antioxidant and anti-inflammatory effects of sesame oil (SO) and its identified compounds as well as further fatty acid profiling and molecular docking study to correlate the interaction of its identified constituents with COX-2. For this, a literature study was made using Google Scholar, Pubmed and SciFinder databases. Literature study demonstrated that SO has potential antioxidant and anti-inflammatory effects in various test systems, including humans, animals and cultured cells through various pathways such as inhibition of COX, non-enzymatic defense mechanism, inhibition of pro-inflammatory cytokines, NF-kB or MAPK signaling and prostaglandin synthesis pathway. Fatty acidanalysis of SO using gas chromatography identified known 9 fatty acids.In-silico study revealed thatsesamin, sesaminol, sesamolin, stigmasterol, Δ5-avenasterol, and Δ7-avenasterol(-9.6 to -10.7 kcal/mol) were the most efficient ligand for interaction and binding with COX-2. The known fatty acid were also showed binding efficiency with COX-2 to some extent (-6.0 to -8.4 kcal/mol).In summary, it is evident that sesame oil may be one of promising traditional medicine that we could use in the prevention and management of diseases associated with oxidative stress and inflammation.
| Item Type: | Article |
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| Additional Information: | This is the peer reviewed version of the following article: Afroz, M, Zihad, SMNK, Uddin, SJ, et al. A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking. Phytotherapy Research. 2019; 33, 2585– 2608., which has been published in final form at https://dx.doi.org/10.1002/ptr.6428. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Uncontrolled Keywords: | 11 Medical and Health Sciences, 03 Chemical Sciences, 06 Biological Sciences |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Wiley |
| Date Deposited: | 14 Jun 2019 09:16 |
| Last Modified: | 04 Sep 2021 09:17 |
| DOI or ID number: | 10.1002/ptr.6428 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/10871 |
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