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Canaparo, R, Foglietta, F, Giuntini, F, Della Pepa, C, Dosio, F and Serpe, L (2019) Recent Developments in Antibacterial Therapy: Focus on Stimuli-Responsive Drug-Delivery Systems and Therapeutic Nanoparticles. Molecules, 24 (10). ISSN 1420-3049
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Recent Developments in Antibacterial Therapy Focus on Stimuli-Responsive Drug-Delivery Systems and Therapeutic Nanoparticles.pdf - Published Version Available under License Creative Commons Attribution. Download (751kB) | Preview |
Abstract
Conventional drugs used for antibacterial therapy display several limitations. This is not due to antibiotics being ineffective, but rather due to their low bioavailability, limited penetration to sites of infection and the rise of drug-resistant bacteria. Although new delivery systems (e.g., nanoparticles) that are loaded with antibacterial drugs have been designed to overcome these limitations, therapeutic efficacy does not seem to have improved. Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects. These stimuli can either be exogenous (e.g., light, ultrasound) or endogenous (e.g., pH, variation in redox gradient, enzymes). This promising therapeutic approach relies on advances in materials science and increased knowledge of microorganism growth and biofilm formation. This review provides an overview in the field of antibacterial drug-delivery systems and nanoantibiotics that benefit from a response to specific triggers, and also presents a number of future prospects
| Item Type: | Article |
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| Uncontrolled Keywords: | 0305 Organic Chemistry |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | MDPI AG |
| Related URLs: | |
| Date Deposited: | 16 Feb 2022 12:06 |
| Last Modified: | 16 Feb 2022 12:15 |
| DOI or ID number: | 10.3390/molecules24101991 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/11057 |
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