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The differential effects of ecstasy/polydrug use on executive components: shifting, inhibition, updating and access to semantic memory

Montgomery, C, Fisk, JE, Newcombe, R and Murphy, PN (2005) The differential effects of ecstasy/polydrug use on executive components: shifting, inhibition, updating and access to semantic memory. Psychopharmacology, 182 (2). pp. 262-276. ISSN 1432-2072

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Recent theoretical models suggest that the central executive may not be a unified structure. The present study explored the nature of central executive deficits in ecstasy users.

In study 1, 27 ecstasy users and 34 non-users were assessed using tasks to tap memory updating (computation span; letter updating) and access to long-term memory (a semantic fluency test and the Chicago Word Fluency Test). In study 2, 51 ecstasy users and 42 non-users completed tasks that assess mental set switching (number/letter and plus/minus) and inhibition (random letter generation).

MANOVA revealed that ecstasy users performed worse on both tasks used to assess memory updating and on tasks to assess access to long-term memory (C- and S-letter fluency). However, notwithstanding the significant ecstasy group-related effects, indices of cocaine and cannabis use were also significantly correlated with most of the executive measures. Unexpectedly, in study 2, ecstasy users performed significantly better on the inhibition task, producing more letters than non-users. No group differences were observed on the switching tasks. Correlations between indices of ecstasy use and number of letters produced were significant.

The present study provides further support for ecstasy/polydrug-related deficits in memory updating and in access to long-term memory. The surplus evident on the inhibition task should be treated with some caution, as this was limited to a single measure and has not been supported by our previous work.

Item Type: Article
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s00213-005-0065-9
Uncontrolled Keywords: 11 Medical And Health Sciences, 17 Psychology And Cognitive Sciences
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Natural Sciences & Psychology (closed 31 Aug 19)
Publisher: Springer Verlag
Related URLs:
Date Deposited: 20 May 2015 12:32
Last Modified: 04 Sep 2021 14:22
DOI or ID number: 10.1007/s00213-005-0065-9
URI: https://researchonline.ljmu.ac.uk/id/eprint/1106
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