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Extraction of artefactual MRS patterns from a large database using non-negative matrix factorization

Hernández-Villegas, Y, Ortega Martorell, S, Arus, C, Vellido, A and Julia-Sape, M (2019) Extraction of artefactual MRS patterns from a large database using non-negative matrix factorization. NMR in Biomedicine. ISSN 0952-3480

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Despite the success of automated pattern recognition methods in problems of human brain tumor diagnostic classification, limited attention has been paid to the issue of automated data quality assessment in the field of MRS for neuro-oncology. Beyond some early attempts to address this issue, the current standard in practice is MRS quality control through human (expert-based) assessment. One aspect of automatic quality control is the problem of detecting artefacts in MRS data. Artefacts, whose variety has already been reviewed in some detail and some of which may even escape human quality control, have a negative influence in pattern recognition methods attempting to assist tumor characterization. The automatic detection of MRS artefacts should be beneficial for radiology as it guarantees more reliable tumor characterizations, as well as the development of more robust pattern recognition-based tumor classifiers and more trustable MRS data processing and analysis pipelines. Feature extraction methods have previously been used to help distinguishing between good and bad quality spectra to apply subsequent supervised pattern recognition techniques. In this study, we apply feature extraction differently and use a variant of a method for blind source separation, namely Convex Non-Negative Matrix Factorization, to unveil MRS signal sources in a completely unsupervised way. We hypothesize that, while most sources will correspond to the different tumor patterns, some of them will reflect signal artefacts. The experimental work reported in this paper, analyzing a combined short and long echo time 1H-MRS database of more than 2000 spectra acquired at 1.5T and corresponding to different tumor types and other anomalous masses, provides a first proof of concept that points to the possible validity of this approach.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Hernández‐Villegas, Y, Ortega‐Martorell, S, Arús, C, Vellido, A, Julià‐Sapé, M. Extraction of artefactual MRS patterns from a large database using non‐negative matrix factorization. NMR in Biomedicine. 2019;e4193. which has been published in final form at https://doi.org/10.1002/nbm.4193. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
Uncontrolled Keywords: 1103 Clinical Sciences, 0304 Medicinal and Biomolecular Chemistry, 0903 Biomedical Engineering
Subjects: Q Science > QA Mathematics
Q Science > QR Microbiology
Divisions: Applied Mathematics (merged with Comp Sci 10 Aug 20)
Publisher: Wiley
Date Deposited: 02 Sep 2019 09:09
Last Modified: 04 Sep 2021 08:57
URI: https://researchonline.ljmu.ac.uk/id/eprint/11245
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