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Matthews, BJ, Dudchenko, O, Kingan, SB, Koren, S, Antoshechkin, I, Crawford, JE, Glassford, WJ, Herre, M, Redmond, SN, Rose, NH, Weedall, GD, Wu, Y, Batra, SS, Brito-Sierra, CA, Buckingham, SD, Campbell, CL, Chan, S, Cox, E, Evans, BR, Fansiri, T , Filipovic, I, Fontaine, A, Gloria-Soria, A, Hall, R, Joardar, VS, Jones, AK, Kay, RGG, Kodali, VK, Lee, J, Lycett, GJ, Mitchell, SN, Muehling, J, Murphy, MR, Omer, AD, Partridge, FA, Peluso, P, Aiden, AP, Ramasamy, V, Rasic, G, Roy, S, Saavedra-Rodriguez, K, Sharan, S, Sharma, A, Smith, ML, Turner, J, Weakley, AM, Zhao, Z, Akbari, OS, Black, WC, Cao, H, Darby, AC, Hill, CA, Johnston, JS, Murphy, TD, Raikhel, AS, Sattelle, DB, Sharakhov, IV, White, BJ, Zhao, L, Aiden, EL, Mann, RS, Lambrechts, L, Powell, JR, Sharakhova, MV, Tu, Z, Robertson, HM, McBride, CS, Hastic, AR, Korlach, J, Neafsey, DE, Phillippy, AM and Vosshall, LB (2018) Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature, 563 (7732). pp. 501-507. ISSN 0028-0836
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Improved reference genome of Aedes aegypti informs arbovirus vector control.pdf - Published Version Available under License Creative Commons Attribution. Download (6MB) | Preview |
Abstract
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.
| Item Type: | Article |
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| Uncontrolled Keywords: | Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; READ ALIGNMENT; GENE-COMPLEX; DE-NOVO; MOSQUITO; SEX; CHROMOSOME; CHROMATIN; PROGRAM; LOCI; HOX |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology > QR355 Virology |
| Divisions: | Biological & Environmental Sciences (from Sep 19) |
| Publisher: | Nature Publishing Group |
| Related URLs: | |
| Date Deposited: | 04 Oct 2019 11:44 |
| Last Modified: | 04 Sep 2021 08:45 |
| DOI or ID number: | 10.1038/s41586-018-0692-z |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/11473 |
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