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Vazquez, NP, Harding, SP, Heimann, H, Czanner, G and Knox, PC (2018) Radial shape discrimination testing for new-onset neovascular age-related macular degeneration in at-risk eyes. PLoS One, 13 (11). ISSN 1932-6203
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Radial shape discrimination testing for new-onset neovascular age-related macular degeneration in at-risk eyes.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
We investigated the performance of the handheld radial shape discrimination (hRSD) test in detecting the development of neovascular AMD (nAMD) in a prospective, longitudinal, observational study. Patients diagnosed with unilateral nAMD, with no nAMD in the othereye (the study eye, SE), completed the hRSD test on consecutive, routine clinic visits up toa maximum of 12, or until they were diagnosed with nAMD in the SE based on slit-lamp biomicroscopy and spectral-domain OCT assessment, with fluorescein angiography confirmation. Masked grading was carried out to confirm the diagnosis of nAMD, and to ensure nocases of nAMD were missed. Receiver operating characteristics (ROC) analysis was used to explore the diagnostic performance of the hRSD test relative to clinical diagnosis. Data were available from 179 patients of whom 19 (10.6%; “converters”) developed nAMD in the SE. The mean hRSD threshold at conversion was -0.47 (95% CI -0.38 to -0.55) logMAR compared to -0.53 (-0.50 to -0.57) logMAR in 160 non-converters. hRSD threshold in the converters began to decline 190 days before diagnosis of nAMD. The ROC curve demonstrated that at an hRSD cut-off of -0.60 logMAR, sensitivity was 0.79 (0.54–0.94) with a specificity of 0.54 (0.46–0.62); positive and negative predictive values were 0.16 and 0.96 respectively. We conclude that the hRSD test has moderate sensitivity for detecting the earliest stages of nAMD in the at-risk fellow eyes of patients with unilateral nAMD, compared to clinical diagnosis. Given its relative inexpensiveness, ease of use and the inherent connectivity of the platforms it can be presented on, it may have a role in early detection of nAMD in the population at large.
| Item Type: | Article |
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| Uncontrolled Keywords: | Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; CHOROIDAL NEOVASCULARIZATION; MONITORING-SYSTEM; VISUAL OUTCOMES; HYPERACUITY; RANIBIZUMAB; AMD; PREVALENCE; MANAGEMENT; VISION; DEVICE |
| Subjects: | R Medicine > RE Ophthalmology |
| Divisions: | Applied Mathematics (merged with Comp Sci 10 Aug 20) |
| Publisher: | Public Library of Science |
| Related URLs: | |
| Date Deposited: | 09 Oct 2019 11:09 |
| Last Modified: | 04 Sep 2021 08:44 |
| DOI or ID number: | 10.1371/journal.pone.0207342 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/11496 |
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