Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Exercise-induced vasodilation is not impaired following radial artery catheterization in coronary artery disease patients.

Tryfonos, A, Cocks, MS, Mills, J, Green, DJ and Dawson, EA (2020) Exercise-induced vasodilation is not impaired following radial artery catheterization in coronary artery disease patients. Journal of Applied Physiology (1985), 128 (1). pp. 422-428. ISSN 8750-7587

[img]
Preview
Text
Exercise-induced vasodilation is not impaired following radial artery catheterization in coronary artery disease patients.pdf - Accepted Version

Download (606kB) | Preview

Abstract

Diagnosis and treatment for coronary artery disease (CAD) often involves angiography and/or percutaneous coronary intervention. However, the radial artery catheterization required during both procedures may result in acute artery dysfunction/damage. Whilst exercise-based rehabilitation is recommended for CAD patients following catheterization, it is not known if there is a period when exercise may be detrimental due to catheter-induced damage. Animal studies have demonstrated exercise-induced paradoxical vasoconstriction post-catheterization. This study aimed to examine arterial responses to acute exercise following catheterization. Thirty-three CAD patients (65.8±7.3yr, 31.5±6.3kg.m-2, 82%♂) undergoing transradial catheterization were assessed pre- and 1 week post-catheterization. Radial artery (RA) diameter and shear rate were assessed during handgrip exercise (HE), in both the catheterized (CATH) and control (CON) arms. Endothelial function was also assessed via simultaneous bilateral radial flow mediated dilation (FMD) at both time-points. We found that the increase in RA diameter and shear stress in response to HE (P<0.0001) was maintained post-catheterization in both the CATH and CON arms, whereas FMD following catheterization was impaired in the CATH [6.5±3.3% to 4.7±3.5% (P=0.005)] but not in the CON [6.2±2.6% to 6.4±3.5% (P=0.797)] limb. Whilst endothelial dysfunction, assessed by FMD, was apparent 1 week post-catheterization, the ability of the RA to dilate in response to exercise was not impaired. The impact of catheterization and consequent endothelial denudation on vascular dys/function in humans may therefore be stimulus specific and a highly level of redundancy appears to exist that preserves exercise-mediated vasodilator responses.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences, 11 Medical and Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Amercian Physiological Society
Related URLs:
Date Deposited: 17 Aug 2020 09:57
Last Modified: 04 Sep 2021 08:05
DOI or ID number: 10.1152/japplphysiol.00695.2019
URI: https://researchonline.ljmu.ac.uk/id/eprint/12072
View Item View Item