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Hulshof, HG, van Dijk, APJ, Hopman, MTE, van der Sluijs, CF, George, KP, Oxborough, D and Thijssen, DHJ (2020) The Acute Impact of Changes to Haemodynamic Load on the Left Ventricular Strain-Volume Relationship in Young and Older Men. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. ISSN 0363-6119
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The Acute Impact of Changes to Haemodynamic Load on the Left Ventricular Strain-Volume Relationship in Young and Older Men..pdf - Accepted Version Download (1MB) | Preview |
Abstract
OBJECTIVES: Chronic changes in left ventricular (LV) haemodynamics, for example induced by increased afterload (i.e., hypertension), mediate changes in LV function. This study examined the proof-of-concept that: 1. the LV longitudinal strain (ԑ)-volume loop is sensitive to detect an acute increase in afterload, and 2. these effects differ between healthy young versus older men. METHODS: Thirty-five healthy male volunteers were recruited including 19 young (24±2 yr) and 16 older participants (67±5 yr). Tests were performed prior to, during and after 10-min recovery from acute manipulation of afterload. Real-time haemodynamic data was obtained and LV longitudinal ԑ-volume loops were calculated from 4-chamber images using 2D-echocardiography. RESULTS: Inflation of the anti-G-suit resulted in an immediate increase in heart rate, blood pressure and systemic vascular resistance, and a decrease in stroke volume (all P<0.05). This was accompanied by a decrease in LV peak ԑ, slower slope of the ԑ-volume relationship during early diastole, increase in uncoupling (i.e., compared to systole; little change in ԑ per volume decline during early diastole and large changes in ԑ per volume decline during late diastole) (all P<0.05). All values returned to baseline levels after recovery (all P>0.05). Manipulation of cardiac haemodynamics caused comparable effects in young versus older men (all P>0.05). CONCLUSIONS: Acute increases in afterload immediately change the diastolic phase of the LV longitudinal ԑ-volume loop in young and older men. This supports the potency of the LV longitudinal ԑ-volume loop to provide novel insights into dynamic cardiac function in humans in vivo.
| Item Type: | Article |
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| Uncontrolled Keywords: | 06 Biological Sciences, 11 Medical and Health Sciences |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | American Physiological Society |
| Related URLs: | |
| Date Deposited: | 18 Feb 2020 12:17 |
| Last Modified: | 20 Feb 2023 15:46 |
| DOI or ID number: | 10.1152/ajpregu.00215.2019 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/12276 |
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