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Diment, BC, Fortes, MB, Edwards, JP, Hanstock, HG, Ward, MD, Dunstall, HM, Friedmann, PS and Walsh, NP (2015) Exercise Intensity and Duration Effects on In Vivo Immunity. Medicine and Science in Sports and Exercise, 47 (7). pp. 1390-1398. ISSN 1530-0315
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Exercise Intensity and Duration Effects on In Vivo Immunity.pdf - Accepted Version Download (1MB) | Preview |
Abstract
PURPOSE: To examine the effects of intensity and duration of exercise stress on induction of in vivo immunity in humans using experimental contact hypersensitivity (CHS) with the novel antigen diphenylcyclopropenone (DPCP). METHODS: Sixty-four healthy males completed either 30 min running at 60% V O2peak (30MI), 30 min running at 80% V O2peak (30HI), 120 min running at 60% V O2peak (120MI), or seated rest (CON). Twenty min later, the subjects received a sensitizing dose of DPCP; and 4 wk later, the strength of immune reactivity was quantified by measuring the cutaneous responses to a low dose-series challenge with DPCP on the upper inner arm. Circulating epinephrine, norepinephrine and cortisol were measured before, after, and 1 h after exercise or CON. Next, to understand better whether the decrease in CHS response on 120MI was due to local inflammatory or T-cell-mediated processes, in a crossover design, 11 healthy males performed 120MI and CON, and cutaneous responses to a dose series of the irritant, croton oil (CO), were assessed on the upper inner arm. RESULTS: Immune induction by DPCP was impaired by 120MI (skinfold thickness -67% vs CON; P < 0.05). However, immune induction was unaffected by 30MI and 30HI despite elevated circulating catecholamines (30HI vs pre: P < 0.01) and greater circulating cortisol post 30HI (vs CON; P < 0.01). There was no effect of 120MI on skin irritant responses to CO. CONCLUSIONS: Prolonged moderate-intensity exercise, but not short-lasting high- or short-lasting moderate-intensity exercise, decreases the induction of in vivo immunity. No effect of prolonged moderate-intensity exercise on the skin's response to irritant challenge points toward a suppression of cell-mediated immunity in the observed decrease in CHS. Diphenylcyclopropenone provides an attractive tool to assess the effect of exercise on in vivo immunity.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1106 Human Movement and Sports Sciences, 1117 Public Health and Health Services |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | American College of Sports Medicine |
| Related URLs: | |
| Date Deposited: | 26 Mar 2020 11:29 |
| Last Modified: | 04 Sep 2021 07:43 |
| DOI or ID number: | 10.1249/MSS.0000000000000562 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/12473 |
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