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De Marco, RJ, Thiemann, T, Groneberg, AH, Herget, U and Ryu, S (2016) Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour. Nature Communications, 7. ISSN 2041-1723
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Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour.pdf - Published Version Available under License Creative Commons Attribution. Download (866kB) | Preview |
Abstract
The anterior pituitary is the major link between nervous and hormonal systems, which allow the brain to generate adequate and flexible behaviour. Here, we address its role in mediating behavioural adjustments that aid in coping with acutely threatening environments. For this we combine optogenetic manipulation of pituitary corticotroph cells in larval zebrafish with newly developed assays for measuring goal-directed actions in very short timescales. Our results reveal modulatory actions of corticotroph cell activity on locomotion, avoidance behaviours and stimulus responsiveness directly after the onset of stress. Altogether, the findings uncover the significance of endocrine pituitary cells for rapidly optimizing behaviour in local antagonistic environments.
| Item Type: | Article |
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| Uncontrolled Keywords: | Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; CORTICOSTEROID STRESS AXIS; LARVAL ZEBRAFISH; MINERALOCORTICOID RECEPTORS; ENDOCANNABINOID RELEASE; TARICHA-GRANULOSA; HORMONE; BRAIN; ACTH; EXPRESSION; GLUTAMATE |
| Subjects: | Q Science > QL Zoology |
| Divisions: | Biological & Environmental Sciences (from Sep 19) |
| Publisher: | Nature Publishing Group |
| Related URLs: | |
| Date Deposited: | 20 Mar 2020 11:16 |
| Last Modified: | 04 Sep 2021 07:37 |
| DOI or ID number: | 10.1038/ncomms12620 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/12561 |
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