Coenzyme Q10 Assessment and the Establishment of a Neuronal Cell Model of CoQ10 Deficiency

Heaton, R, Duberley, K and Hargreaves, IP (2020) Coenzyme Q10 Assessment and the Establishment of a Neuronal Cell Model of CoQ10 Deficiency. In: guest, P, (ed.) Clinical and Preclinical Models for Maximizing Healthspan. Springer, pp. 277-287. ISBN 978-1-07-160471-7

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Abstract

Coenzyme Q10 (CoQ10) plays a key role as an electron carrier in the mitochondrial respiratory chain and as a cellular antioxidant molecule. A deficit in CoQ10 status may contribute to disease pathophysiology by causing a failure mitochondrial energy metabolism as well as compromising cellular antioxidant capacity. This chapter outlines the analytical methods used for determining cellular CoQ10 status using high-pressure liquid chromatography with ultraviolet (HPLC-UV) detection. In addition, we present a pharmacological procedure for establishing a human neuronal cell model of CoQ10 deficiency, for use in research studies.

Item Type:	Book Section
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Springer
Date of acceptance:	17 September 2019
Date of first compliant Open Access:	27 March 2022
Date Deposited:	30 Mar 2020 11:39
Last Modified:	27 Mar 2022 00:50
DOI or ID number:	10.1007/978-1-0716-0471-7_19
Editors:	guest, P
URI:	https://researchonline.ljmu.ac.uk/id/eprint/12610

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