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5-Year prognostic value of the right ventricular strain-area loop in patients with pulmonary hypertension.

Hulshof, HG, van Dijk, AP, Hopman, MTE, Heesakkers, H, George, KP, Oxborough, D and Thijssen, DHJ (2020) 5-Year prognostic value of the right ventricular strain-area loop in patients with pulmonary hypertension. European Heart Journal Cardiovascular Imaging, 22 (2). pp. 188-195. ISSN 2047-2412

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AIMS: Patients with pre-capillary pulmonary hypertension (PH) show poor survival, often related to right ventricular (RV) dysfunction. In this study, we assessed the 5-year prognostic value of a novel echocardiographic measure that examines RV function through the temporal relation between RV strain (ϵ) and area (i.e. RV ϵ-area loop) for all-cause mortality in PH patients. METHODS AND RESULTS: Echocardiographic assessments were performed in 143 PH patients (confirmed by right heart catheterization). Transthoracic echocardiography was utilized to assess RV ϵ-area loop. Using receiver operating characteristic curve-derived cut-off values, we stratified patients in low- vs. high-risk groups for all-cause mortality. Kaplan-Meier survival curves and uni-/multivariable cox-regression models were used to assess RV ϵ-area loop's prognostic value (independent of established predictors: age, sex, N-terminal pro B-type natriuretic peptide, 6-min walking distance). During follow-up 45 (31%) patients died, who demonstrated lower systolic slope, peak ϵ, and late diastolic slope (all P < 0.05) at baseline. Univariate cox-regression analyses identified early systolic slope, systolic slope, peak ϵ, early diastolic uncoupling, and early/late diastolic slope to predict all-cause mortality (all P < 0.05), whilst peak ϵ possessed independent prognostic value (P < 0.05). High RV loop-score (i.e. based on number of abnormal characteristics) showed poorer survival compared to low RV loop-score (Kaplan-Meier: P < 0.01). RV loop-score improved risk stratification in high-risk patients when added to established predictors. CONCLUSION: Our data demonstrate the potential for RV ϵ-area loops to independently predict all-cause mortality in patients with pre-capillary PH. The non-invasive nature and simplicity of measuring the RV ϵ-area loop, support the potential clinical relevance of (repeated) echocardiography assessment of PH patients.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of record Hugo G Hulshof, Arie P van Dijk, Maria T E Hopman, Hidde Heesakkers, Keith P George, David L Oxborough, Dick H J Thijssen, 5-Year prognostic value of the right ventricular strain-area loop in patients with pulmonary hypertension, European Heart Journal - Cardiovascular Imaging, , jeaa143 is available online at: https://doi.org/10.1093/ehjci/jeaa143
Uncontrolled Keywords: echocardiography; prognostic value; pulmonary hypertension; right ventricular function; ultrasound
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Sport & Exercise Sciences
Publisher: Oxford University Press (OUP)
Related URLs:
Date Deposited: 13 Jul 2020 13:15
Last Modified: 20 Feb 2023 15:46
DOI or ID number: 10.1093/ehjci/jeaa143
URI: https://researchonline.ljmu.ac.uk/id/eprint/13292
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