Gong, G, Guan, Y-Y, Zhang, Z-L, Rahman, K, Wang, S-J, Zhou, S, Luan, X and Zhang, H (2020) Isorhamnetin: A review of pharmacological effects. Biomedicine & Pharmacotherapy, 128. ISSN 0753-3322

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Abstract

Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. At present, there have been numerous investigations on isorhamnetin, which has the effects of cardiovascular and cerebrovascular protection, anti-tumor, anti-inflammatory, anti-oxidation, organ protection, prevention of obesity, etc. The related mechanisms involve the regulation of PI3K/AKT/PKB, NF-κB, MAPK and other signaling pathways as well as the expression of related cytokines and kinases. Isorhamnetin has a high value of development and application. However, the investigations on its mechanism of action are limited and lack of detailed scientific validation. The manuscript reviewed the pharmacological effects of isorhamnetin and related mechanisms of action for the development of its medicinal properties further.

Item Type:	Article
Uncontrolled Keywords:	1115 Pharmacology and Pharmaceutical Sciences
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Elsevier
Related URLs:	Author
Date Deposited:	07 Aug 2020 12:35
Last Modified:	04 Sep 2021 06:50
DOI or ID number:	10.1016/j.biopha.2020.110301
URI:	https://researchonline.ljmu.ac.uk/id/eprint/13470

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