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Buckley, B, Lip, G and Thijssen, DHJ (2020) The counterintuitive role of exercise in the prevention and cause of atrial fibrillation. AJP - Heart and Circulatory Physiology. ISSN 0363-6135
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Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmia characterised by irregular atrial activity. AF is related to increased risk of thromboembolic events, heart failure, and premature mortality. Recent advances in our understanding of its pathophysiology include a potentially central role for inflammation and presence of cardiovascular risk factors. The role of physical activity and exercise in the development and progression of AF, however, are not yet fully understood. Physical activity is protective for modifiable cardiovascular risk factors, including those associated with AF. Indeed, emerging research has demonstrated beneficial effects of exercise on AF-specific outcomes, including AF recurrence post-ablation. Counterintuitively, the prevalence of AF in veteran endurance athletes seems higher compared to the general population. In this review, we discuss the novel evidence and underlying mechanisms underpinning the role of exercise as medicine in the development and management of AF, but also the counterintuitive detrimental role of excessive endurance exercise. Finally, we advocate regular (but not long-term high-intensity endurance) exercise training as a safe and effective strategy to reduce the risk of incident AF, and to minimise the associated risk of secondary cardiovascular events.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 0606 Physiology, 1116 Medical Physiology |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | American Physiological Society |
| Related URLs: | |
| Date Deposited: | 28 Sep 2020 12:24 |
| Last Modified: | 18 Sep 2021 00:50 |
| DOI or ID number: | 10.1152/ajpheart.00509.2020 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/13737 |
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