Pickles, J (2021) “Can Home-Based High Intensity Interval Training Improve Post Exercise Glycaemic Control in People with Type 1 diabetes?”. Other thesis, Liverpool John Moores University.

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Abstract

Aims: The aims of this study were to investigate: the effects of home-HIIT and home-MICT completed in a postprandial state compared to a non-exercise control period on; i) hypoglycaemia ii) time in range (TIR), and iii) glycaemic variability (GV), for up to 48-hours post exercise in a free-living environment in adults with Type 1 diabetes. A secondary aim was to investigate whether acute changes following exercise influenced 14-day glycaemic control. Methods: 11 adults with Type 1 diabetes (male n=4, female n=7, age 26 ± 7 years, BMI 25.43 ± 4.29 kg.m2, Type 1 diabetes duration 10 ± 8 years) completed a randomised crossover study consisting of three 14-day interventions; 1) home-HIIT, 2) home-MICT and 3) non-exercise control (CON). During exercise intervention the effect of six exercise sessions on subsequent glycaemic control was assessed for up to 48-hours post exercise. CON data was time matched to home-HIIT. Glycaemic control was measured using an Abbot Freestyle Libre flash glucose monitor. Dietary intake and insulin dose were also assessed. Results: Neither home-HIIT or home-MICT increased time spent in serious, clinically significant hypoglycaemia (< 3.0 mmol/L) compared to CON at any period during the 48 hours post exercise (P > 0.05). TIR in home-HIIT was significantly greater during the period immediately after exercise compared to CON (11% [0, 22], P = 0.043) and significantly greater compared to home-MICT during the awake periods on the day following (10% [2, 18], P = 0.013) and second day following exercise (11% [3, 20], P = 0.014). GV, assessed as coefficient of variation (CV) was increased during the nocturnal period on the second day following home-MICT compared to CON (CV = 4% [1, 7] P = 0.008) and home-HIIT (CV = -5% [-8, 2], P = 0.005). This increase in GV translated into an increased nocturnal GV over the 14-day day intervention period in home-MICT compared to home-HIIT (CV = -4% [-8, 0], P = 0.034). Conclusion: In conclusion, both home-HIIT and home-MICT are safe exercise modalities for people with Type 1 diabetes but Home-HIIT may provide more beneficial effects on glycaemic control compared to home-MICT. This study provides novel evidence that exercise affects glycaemic control for up to 48-hours post exercise in people with Type 1 diabetes.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Glycaemic control; Type 1 diabetes; Exercise
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Date Deposited:	29 Jan 2021 09:17
Last Modified:	18 Oct 2022 14:24
DOI or ID number:	10.24377/LJMU.t.00014343
Supervisors:	Cocks, M, Hopkins, N, Thijssen, D and Carter, S
URI:	https://researchonline.ljmu.ac.uk/id/eprint/14343

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