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Buckley, BJR, Harrison, SL, Fazio-Eynullayeva, E, Underhill, P, Lane, DA, Thijssen, DHJ and Lip, GYH (2021) Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation. Journal of Clinical Medicine, 10 (3). ISSN 2077-0383
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Abstract
Progression of atrial fibrillation (AF) is associated with worsened prognosis for cardiovascular events and mortality. Exercise-based-cardiac rehabilitation programmes have shown preliminary promise for primary and secondary prevention of AF. Yet, such interventions are typically reserved for patients with acute coronary syndrome or undergoing revascularization. Using a retrospective cohort design, the present study investigated the association of exercise-based cardiac rehabilitation on the progression of paroxysmal to sustained AF, compared to propensity-matched controls. Patients with a diagnosis of paroxysmal AF were compared between those with and without an electronic medical record of exercise-based cardiac rehabilitation within 6-months of diagnosis. Using cox regression models, we ascertained odds of 2-year incidence for AF progression. This cohort of 9808 patients with paroxysmal AF demonstrated that exercise-based cardiac rehabilitation was associated with 26% lower odds of AF progression (odds ratio 0.74, 95% CI 0.66-0.83) compared to propensity-matched controls. This beneficial effect seemed to vary across patient subgroups. In conclusion, findings revealed that exercise-based cardiac rehabilitation was associated with significantly lower odds of progression from paroxysmal to sustained AF at 2-years follow-up compared to propensity-matched controls.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1103 Clinical Sciences |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | MDPI AG |
| Related URLs: | |
| Date Deposited: | 01 Feb 2021 11:13 |
| Last Modified: | 04 Sep 2021 06:02 |
| DOI or ID number: | 10.3390/jcm10030435 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/14363 |
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