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Roberts, KA, Draijer, R, Hopkins, ND, de Graaf, Y, Holder, SM, Carter, SE, Thijssen, DHJ and Low, DA (2021) Impact of green tea on the deleterious cardiometabolic effects of 7-days unhealthy lifestyle in young healthy males. Physiological Reports, 9 (5). ISSN 2051-817X
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Abstract
PURPOSE: The aim of this study was to examine if catechin-rich green tea abrogates the negative effects of 7-days of physical inactivity and excessive calorie-intake on insulin homeostasis and peripheral vascular function. METHODS: Using a randomized, double-blind, crossover design, twelve healthy men (29 ± 6 yrs) underwent 7-days unhealthy lifestyle (UL), including physical inactivity (-50% steps/day) and overfeeding (+50% kcal/day). This was combined with green tea consumption (UL-tea; 3 doses/day) or placebo (UL-placebo). Before and after each intervention, we examined postprandial blood glucose and insulin (3-h after a 1,202 kcal meal) and upper and lower limb vascular function (flow-mediated dilation (FMD%)) and carotid artery reactivity (CAR%). RESULTS: UL-placebo increased postprandial glucose and insulin, while UL-tea decreased postprandial glucose and insulin (Time*Intervention interaction effects: both p < 0.05). UL-placebo decreased CAR% and femoral FMD%, while UL-tea prevented these effects (Time*Intervention interaction effects of p < 0.04 and p < 0.001, respectively). There was no main effect of Time or Time*Intervention interaction (both p > 0.05) for brachial FMD%. CONCLUSION: Seven days of physical inactivity and overfeeding impair insulin homeostasis and vascular function. These effects were mitigated by a daily intake of catechin-rich green tea.
| Item Type: | Article |
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| Uncontrolled Keywords: | 0606 Physiology, 1103 Clinical Sciences, 1116 Medical Physiology |
| Subjects: | T Technology > TX Home economics > TX341 Nutrition. Foods and food supply Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Wiley Open Access |
| Related URLs: | |
| Date Deposited: | 12 Mar 2021 10:51 |
| Last Modified: | 04 Sep 2021 05:47 |
| DOI or ID number: | 10.14814/phy2.14720 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/14605 |
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