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Impact of green tea on the deleterious cardiometabolic effects of 7-days unhealthy lifestyle in young healthy males.

Roberts, KA, Draijer, R, Hopkins, ND, de Graaf, Y, Holder, SM, Carter, SE, Thijssen, DHJ and Low, DA (2021) Impact of green tea on the deleterious cardiometabolic effects of 7-days unhealthy lifestyle in young healthy males. Physiological Reports, 9 (5). ISSN 2051-817X

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PURPOSE: The aim of this study was to examine if catechin-rich green tea abrogates the negative effects of 7-days of physical inactivity and excessive calorie-intake on insulin homeostasis and peripheral vascular function. METHODS: Using a randomized, double-blind, crossover design, twelve healthy men (29 ± 6 yrs) underwent 7-days unhealthy lifestyle (UL), including physical inactivity (-50% steps/day) and overfeeding (+50% kcal/day). This was combined with green tea consumption (UL-tea; 3 doses/day) or placebo (UL-placebo). Before and after each intervention, we examined postprandial blood glucose and insulin (3-h after a 1,202 kcal meal) and upper and lower limb vascular function (flow-mediated dilation (FMD%)) and carotid artery reactivity (CAR%). RESULTS: UL-placebo increased postprandial glucose and insulin, while UL-tea decreased postprandial glucose and insulin (Time*Intervention interaction effects: both p < 0.05). UL-placebo decreased CAR% and femoral FMD%, while UL-tea prevented these effects (Time*Intervention interaction effects of p < 0.04 and p < 0.001, respectively). There was no main effect of Time or Time*Intervention interaction (both p > 0.05) for brachial FMD%. CONCLUSION: Seven days of physical inactivity and overfeeding impair insulin homeostasis and vascular function. These effects were mitigated by a daily intake of catechin-rich green tea.

Item Type: Article
Uncontrolled Keywords: 0606 Physiology, 1103 Clinical Sciences, 1116 Medical Physiology
Subjects: T Technology > TX Home economics > TX341 Nutrition. Foods and food supply
Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley Open Access
Related URLs:
Date Deposited: 12 Mar 2021 10:51
Last Modified: 04 Sep 2021 05:47
DOI or ID number: 10.14814/phy2.14720
URI: https://researchonline.ljmu.ac.uk/id/eprint/14605
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