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Ashworth, E, Schiöth, HB and Brooks, SJ (2021) Neural activation of anxiety and depression in children and young people: A systematic meta-analysis of fMRI studies. Psychiatry Research: Neuroimaging, 311. ISSN 0925-4927
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Neural activation of anxiety and depression in children and young people A systematic meta-analysis of fMRI studies.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Functional magnetic resonance imaging (fMRI) studies consistently demonstrate altered neural activation in youth experiencing anxiety and depression in a way that is distinct from adult-onset disorders. However, there is a paucity of research systematically reviewing this, and no meta-analyses have been conducted using Activation Likelihood Estimation (ALE). The present study conducted a systematic literature search to identify fMRI studies in youth (age 4-18) with depression or anxiety disorders. 48 studies with over 2000 participants were identified that met the inclusion criteria. Significant foci were extracted. Five ALE meta-analyses were conducted: a) activation for both anxiety disorders and depression; b) activation for anxiety disorders only; c) activation for depression only; d) deactivation for both anxiety disorders and depression; e) deactivation for depression. Results indicated significant clusters of increased activation in the bilateral amygdala for youth with internalising disorders, and specifically for those with anxiety disorders. Significant increased activation extended into the dorsal anterior cingulate, entorhinal cortex, the putamen, and the medial and lateral globus pallidus in youth with anxiety disorders. These findings help to detail the nature of anxiety being an amygdala hyperactivity disorder, whilst also defining the distinction between neural activation patterns in anxiety and depression.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1103 Clinical Sciences, 1109 Neurosciences, 1702 Cognitive Sciences |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Psychology (from Sep 2019) |
| Publisher: | Elsevier |
| Date Deposited: | 15 Mar 2021 10:33 |
| Last Modified: | 04 Sep 2021 05:47 |
| DOI or ID number: | 10.1016/j.pscychresns.2021.111272 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/14606 |
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