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Tryfonos, A, Cocks, MS, Rasoul, D, Mills, J, Green, DJ and Dawson, EA (2020) Impact of catheterization on shear-mediated arterial dilation in healthy young men. European Journal of Applied Physiology, 120 (11). pp. 2525-2532. ISSN 1439-6319
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Impact of catheterization on shear-mediated arterial dilation in healthy young men.pdf - Published Version Available under License Creative Commons Attribution. Download (628kB) | Preview |
Abstract
Purpose; Animal studies have shown that endothelial denudation abolishes vasodilation in response to increased shear stress. Interestingly, shear-mediated dilation has been reported to be reduced, but not abolished, in coronary artery disease (CAD) patients following catheterization. However, it is not known whether this resulted from a priori endothelial dysfunction in this diseased population. In this study, we evaluated shear-mediated dilation following catheterization in healthy young men.
Methods: Twenty-six (age: 24.4 ± 3.8 years, BMI: 24.3 ± 2.8 kg m−2, VO2peak: 50.5 ± 8.8 ml/kg/min) healthy males underwent unilateral transradial catheterization. Shear-mediated dilation of both radial arteries was measured using flow-mediated dilation (FMD) pre-, and 7 days post-catheterization.
Results: FMD was reduced in the catheterized arm [9.3 ± 4.1% to 4.3 ± 4.1% (P < 0.001)] post-catheterization, whereas no change was observed in the control arm [8.4 ± 3.8% to 7.3 ± 3.8% (P = 0.168)]. FMD was completely abolished in the catheterized arm in five participants. Baseline diameter (P = 0.001) and peak diameter during FMD (P = 0.035) were increased in the catheterized arm 7 days post-catheterization (baseline: 2.3 ± 0.3 to 2.6 ± 0.2 mm, P < 0.001, peak: 2.5 ± 0.3 to 2.7 ± 0.3 mm, P = 0.001), with no change in the control arm (baseline: 2.3 ± 0.3 to 2.3 ± 0.3 mm, P = 0.288, peak: 2.5 ± 0.3 to 2.5 ± 0.3 mm, P = 0.608).
Conclusion: This is the first study in young healthy individuals with intact a priori endothelial function to provide evidence of impaired shear-mediated dilation following catheterization. When combined with earlier studies in CAD patients, our data suggest the catheterization impairs artery function in humans.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1106 Human Movement and Sports Sciences |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Springer |
| Related URLs: | |
| Date Deposited: | 23 Mar 2021 12:40 |
| Last Modified: | 04 Sep 2021 05:43 |
| DOI or ID number: | 10.1007/s00421-020-04473-8 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/14666 |
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