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Guilherme, JP, Bosnyák, E, Semenova, E, Szmodis, M, Griff, A, Móra, Á, Almási, G, Trájer, E, Udvardy, A, Kostryukova, E, Borisov, O, Larin, A, Andryushchenko, L, Akimov, E, Generozov, E, Ahmetov, II, Tóth, M and Lancha Junior, A (2020) The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake. Biology of Sport, 38 (3). pp. 465-474. ISSN 0860-021X
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The MCT1 gene Glu490Asp polymorphism (rs1049434).pdf - Published Version Available under License Creative Commons Attribution Share Alike. Download (585kB) | Preview |
Abstract
The purpose of this study was to explore the association of the MCT1 gene Glu490Asp polymorphism (rs1049434) with athletic status and performance of endurance athletes. A total of 1,208 Brazilians (318 endurance athletes and 890 non-athletes) and 867 Europeans (315 endurance athletes and 552 non-athletes) were evaluated in a case–control approach. Brazilian participants were classified based on self-declared ethnicity to test whether the polymorphism was different between Caucasians and Afro-descendants. Moreover, 66 Hungarian athletes underwent an incremental test until exhaustion to assess blood lactate levels, while 46 Russian athletes had their maximum oxygen uptake ( O2max) compared between genotypes. In the Brazilian cohort, the major T-allele was more frequent in Caucasian top-level competitors compared to their counterparts of lower competitive level (P = 0.039), and in Afro-descendant athletes compared to non-athletes (P = 0.015). Similarly, the T-allele was more frequent in European athletes (P = 0.029). Meta-analysis of the Brazilian and European cohorts confirmed that the T-allele is over-represented in endurance athletes (OR: 1.48, P = 0.03), especially when Afro-descendant athletes were included in the meta-analysis (OR: 1.58, P = 0.005). Furthermore, carriers of the T/T genotype accumulated less blood lactate in response to intense effort (P< 0.01) and exhibited higher O2max (P = 0.04). In conclusion, the Glu490Asp polymorphism was associated with endurance athletic status and performance. Our findings suggest that, although ethnic differences may exist, the presence of the major T-allele (i.e., the Glu-490 allele) favours endurance performance more than the mutant A-allele (i.e., the 490-Asp allele).
| Item Type: | Article |
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| Uncontrolled Keywords: | 1106 Human Movement and Sports Sciences |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Termedia Publishing |
| Date Deposited: | 29 Mar 2021 09:54 |
| Last Modified: | 04 Sep 2021 05:41 |
| DOI or ID number: | 10.5114/biolsport.2021.101638 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/14701 |
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