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Hernon, J and Thomas, LB (2021) SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE‐ABC): study protocol for a multi‐centre randomised controlled trial. Colorectal Disease. ISSN 1462-8910
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SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE‐ABC) study protocol for a multi‐centre randomised controlled trial.pdf - Accepted Version Download (815kB) | Preview |
Abstract
Background: Exercise programmes can increase cardiopulmonary reserve and functional capacity prior to surgery and can improve clinical, functional and survival outcomes after a colorectal cancer diagnosis. However, the impact of pre- and post-operative exercise on post-operative recovery outcomes and longer-term health-related quality of life are unknown, thus there is a need for high quality randomised controlled trials.
Method: SupPoRtive Exercise Programmes for Accelerating REcovery after major Abdominal Cancer surgery (PREPARE-ABC) is a 3-arm multi-centre randomised controlled trial with internal pilot. The primary objective is to assess the effects of pre- and post-operative exercise on surgical outcomes and longer-term health-related quality of life in cancer patients undergoing colorectal resection. PREPARE-ABC aims to randomise 1146 patients at the individual level (1:1:1) to either hospital-supervised exercise, home-supported exercise or treatment as usual. The primary outcomes are short-term (30-day) morbidity using the Clavien-Dindo classification and longer-term healthrelated quality of life using the Medical Outcomes Study Health Questionnaire (SF-36). Secondary outcomes include cardiopulmonary fitness, physical activity behaviour change, psychological health status and cost-effectiveness. A process evaluation of intervention delivery and usual care also will be undertaken.
Discussion: This is the first UK-based definitive randomised controlled trial to investigate the effects of pre- and post-operative exercise on short-term post-operative health outcomes and longer-term health-related quality of life in colorectal cancer patients. The trial will yield robust clinical and costeffectiveness data to underpin clinical guidance on how exercise programmes should be implemented in the routine management of patients undergoing major colorectal cancer surgery.
| Item Type: | Article |
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| Additional Information: | This is the peer reviewed version of the following article:On behalf of the PREPARE-ABC Trial Collaborative. SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE-ABC): Study protocol for a multicentre randomized controlled trial. Colorectal Dis. 2021; 00: 1– 11. which has been published in final form at https://dx.doi.org/10.1111/codi.15805. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Uncontrolled Keywords: | 1103 Clinical Sciences |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Wiley |
| Date Deposited: | 20 Jul 2021 09:18 |
| Last Modified: | 02 Sep 2022 00:50 |
| DOI or ID number: | 10.1111/codi.15805 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/15305 |
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