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Pontzer, H, Yamada, Y, Sagayama, H, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SG, Close, GL, Cooper, JA, Cooper, R , Das, SK, Dugas, LR, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Martin, C, Medin, AC, Meijer, EP, Morehen, JC, Morton, JP, Neuhouser, ML, Nicklas, TA, Ojiambo, RM, Pietiläinen, KH, Pitsiladis, YP, Plange-Rhule, J, Plasqui, G, Prentice, RL, Rabinovich, RA, Racette, SB, Raichlen, DA, Ravussin, E, Reynolds, RM, Roberts, SB, Schuit, AJ, Sjödin, AM, Stice, E, Urlacher, SS, Valenti, G, Van Etten, LM, Van Mil, EA, Wells, JCK, Wilson, G, Wood, BM, Yanovski, J, Yoshida, T, Zhang, X, Murphy-Alford, AJ, Loechl, C, Luke, AH, Rood, J, Schoeller, DA, Westerterp, KR, Wong, WW, Speakman, JR and IAEA DLW Database Consortium, (2021) Daily energy expenditure through the human life course. Science, 373 (6556). ISSN 0036-8075
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Pontzer et al 2021 Accepted.pdf - Accepted Version Download (2MB) | Preview |
Abstract
Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.
| Item Type: | Article |
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| Additional Information: | This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 13/08/2021 Vol 373, DOI: https://dx.doi.org/10.1126/science.abe5017 |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | American Association for the Advancement of Science |
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| Date Deposited: | 19 Aug 2021 10:05 |
| Last Modified: | 04 Sep 2021 05:08 |
| DOI or ID number: | 10.1126/science.abe5017 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/15386 |
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