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McNeill, AM, Monk, RL, Qureshi, AW, Makris, S, Cazzato, V and Heim, D (2021) Elevated ad libitum alcohol consumption following continuous theta burst stimulation to the left-dorsolateral prefrontal cortex is partially mediated by changes in craving. Cognitive, Affective, & Behavioral Neuroscience. ISSN 1530-7026
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Elevated ad libitum alcohol consumption following continuous theta burst stimulation to the left-dorsolateral prefrontal cortex is partially mediated by changes in craving.pdf - Published Version Available under License Creative Commons Attribution. Download (997kB) | Preview |
Abstract
Previous research indicates that following alcohol intoxication, activity in prefrontal cortices is reduced, linking to changes in associated cognitive processes, such as inhibitory control, attentional bias (AB), and craving. While these changes have been implicated in alcohol consumption behaviour, it has yet to be fully illuminated how these frontal regions and cognitive processes interact to govern alcohol consumption behaviour. The current preregistered study applied continuous theta burst transcranial magnetic stimulation (cTBS) to examine directly these relationships while removing the wider pharmacological effects of alcohol. A mixed design was implemented, with cTBS stimulation to right and left dorsolateral prefrontal cortex (DLPFC), the medial orbital frontal cortex (mOFC) and Vertex, with measures of inhibitory control, AB, and craving taken both pre- and post-stimulation. Ad libitum consumption was measured using a bogus taste task. Results suggest that rDLPFC stimulation impaired inhibitory control but did not significantly increase ad libitum consumption. However, lDLPFC stimulation heightened craving and increased consumption, with findings indicating that changes in craving partially mediated the relationship between cTBS stimulation of prefrontal regions and ad libitum consumption. Medial OFC stimulation and AB findings were inconclusive. Overall, results implicate the left DLPFC in the regulation of craving, which appears to be a prepotent cognitive mechanism by which alcohol consumption is driven and maintained.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Psychology (from Sep 2019) |
| Publisher: | Springer |
| Date Deposited: | 23 Aug 2021 11:31 |
| Last Modified: | 04 Sep 2021 05:07 |
| DOI or ID number: | 10.3758/s13415-021-00940-7 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/15397 |
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