Hall, ECR, Baumert, P, Larruskain, J, Gil, SM, Lekue, JA, Rienzi, E, Moreno, S, Tannure, M, Murtagh, CF, Ade, JD, Squires, P, Orme, P, Anderson, L, Brownlee, TE, Whitworth‐Turner, CM, Morton, JP, Drust, B, Williams, AG and Erskine, RM (2021) The genetic association with injury risk in male academy soccer players depends on maturity status. Scandinavian Journal of Medicine & Science in Sports. ISSN 0905-7188

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Abstract

It is currently unknown if injury risk is associated with genetic variation in academy soccer players (ASP). We investigated whether nine candidate single nucleotide polymorphisms were associated (individually and in combination) with injury in ASP at different stages of maturation. Saliva samples and one season’s injury records were collected from 402 Caucasian male ASP from England, Spain, Uruguay and Brazil, whose maturity status was defined as pre- or post-peak height velocity (PHV). Pre-PHV COL5A1 rs12722 CC homozygotes had relatively higher prevalence of any musculoskeletal soft-tissue (22.4% vs. 3.0%, P=0.018) and ligament (18.8% vs. 11.8%, P=0.029) injury than T-allele carriers, while VEGFA rs2010963 CC homozygotes had greater risk of ligament/tendon injury than G-allele carriers. Post-PHV IL6 rs1800795 CC homozygotes had a relatively higher prevalence of any (67.6% vs. 40.6%, P=0.003) and muscle (38.2% vs. 19.2%, P=0.013) injuries than G-allele carriers. Relatively more post-PHV EMILIN1 rs2289360 CC homozygotes suffered any injury than CT and TT genotypes (56.4% vs. 40.3% and 32.8%, P=0.007), while the ‘protective’ EMILIN1 TT genotype was more frequent in post- than pre-PHV ASP (22.3 vs. 10.0%, P=0.008). Regardless of maturity status, T-alleles of ACTN3 rs1815739 and EMILIN1 rs2289360 were associated with greater absence following ankle injury, while the MMP3 rs679620 T-allele and MYLK rs28497577 GT genotype were associated with greater absence following knee injury. The combination of injury-associated genotypes was greater in injured vs. non-injured ASP. This study is the first to demonstrate that a genetic association exists with injury prevalence in ASP, which differs according to maturity status.

Item Type:	Article
Additional Information:	This is the peer reviewed version of the following article: Hall, ECR, Baumert, P, Larruskain, J, et al. The genetic association with injury risk in male academy soccer players depends on maturity status. Scand J Med Sci Sports. 2021; 00: 1– 13., which has been published in final form at https://doi.org/10.1111/sms.14077. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited
Uncontrolled Keywords:	1106 Human Movement and Sports Sciences, 1116 Medical Physiology
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	Wiley
Date Deposited:	13 Oct 2021 14:26
Last Modified:	18 Oct 2022 00:50
DOI or ID number:	10.1111/sms.14077
URI:	https://researchonline.ljmu.ac.uk/id/eprint/15640

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