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Ginevičienė, V, Jakaitienė, A, Utkus, A, Hall, ECR, Semenova, EA, Andryushchenko, LB, Larin, AK, Moreland, E, Generozov, EV and Ahmetov, II (2021) CKM Gene rs8111989 Polymorphism and Power Athlete Status. Genes (Basel), 12 (10). ISSN 2073-4425
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Abstract
Multiple genetic variants are known to influence athletic performance. These include polymorphisms of the muscle-specific creatine kinase (CKM) gene, which have been associated with endurance and/or power phenotypes. However, independent replication is required to support those findings. The aim of the present study was to determine whether the CKM (rs8111989, c.*800A>G) polymorphism is associated with power athlete status in professional Russian and Lithuanian competitors. Genomic DNA was collected from 693 national and international standard athletes from Russia (n = 458) and Lithuania (n = 235), and 500 healthy non-athlete subjects from Russia (n = 291) and Lithuania (n = 209). Genotyping for the CKM rs8111989 (A/G) polymorphism was performed using PCR or micro-array analysis. Genotype and allele frequencies were compared between all athletes and non-athletes, and between non-athletes and athletes, segregated according to population and sporting discipline (from anaerobic-type events). No statistically significant differences in genotype or allele frequencies were observed between non-athletes and power athletes (strength-, sprint- and speed/strength-oriented) athletes. The present study reports the non-association of the CKM rs8111989 with elite status in athletes from sports in which anaerobic energy pathways determine success.
| Item Type: | Article |
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| Uncontrolled Keywords: | 0604 Genetics |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | MDPI |
| Related URLs: | |
| Date Deposited: | 05 Nov 2021 14:01 |
| Last Modified: | 09 Nov 2021 09:29 |
| DOI or ID number: | 10.3390/genes12101499 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/15747 |
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