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CKM Gene rs8111989 Polymorphism and Power Athlete Status.

Ginevičienė, V, Jakaitienė, A, Utkus, A, Hall, ECR, Semenova, EA, Andryushchenko, LB, Larin, AK, Moreland, E, Generozov, EV and Ahmetov, II (2021) CKM Gene rs8111989 Polymorphism and Power Athlete Status. Genes (Basel), 12 (10). ISSN 2073-4425

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Multiple genetic variants are known to influence athletic performance. These include polymorphisms of the muscle-specific creatine kinase (CKM) gene, which have been associated with endurance and/or power phenotypes. However, independent replication is required to support those findings. The aim of the present study was to determine whether the CKM (rs8111989, c.*800A>G) polymorphism is associated with power athlete status in professional Russian and Lithuanian competitors. Genomic DNA was collected from 693 national and international standard athletes from Russia (n = 458) and Lithuania (n = 235), and 500 healthy non-athlete subjects from Russia (n = 291) and Lithuania (n = 209). Genotyping for the CKM rs8111989 (A/G) polymorphism was performed using PCR or micro-array analysis. Genotype and allele frequencies were compared between all athletes and non-athletes, and between non-athletes and athletes, segregated according to population and sporting discipline (from anaerobic-type events). No statistically significant differences in genotype or allele frequencies were observed between non-athletes and power athletes (strength-, sprint- and speed/strength-oriented) athletes. The present study reports the non-association of the CKM rs8111989 with elite status in athletes from sports in which anaerobic energy pathways determine success.

Item Type: Article
Uncontrolled Keywords: 0604 Genetics
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: MDPI
Related URLs:
Date Deposited: 05 Nov 2021 14:01
Last Modified: 09 Nov 2021 09:29
DOI or ID number: 10.3390/genes12101499
URI: https://researchonline.ljmu.ac.uk/id/eprint/15747
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