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Visser, LNC, Dubbelman, MA, Verrijp, M, Wanders, L, Pelt, S, Zwan, MD, Thijssen, DHJ, Wouters, H, Sikkes, SAM, van Hout, HPJ and van der Flier, WM (2021) The Cognitive Online Self-Test Amsterdam (COST-A): Establishing norm scores in a community-dwelling population. Alzheimers & Dementia: Diagnosis, Assessment & Disease Monitoring, 13 (1). ISSN 2352-8729
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Abstract
Background: Heightened public awareness about Alzheimer's disease and dementia increases the need for at-home cognitive self-testing. We offered Cognitive Online Self-Test Amsterdam (COST-A) to independent groups of cognitively normal adults and investigated the robustness of a norm-score formula and cutoff. Methods: Three thousand eighty-eight participants (mean age ± standard deviation = 61 ± 12 years, 70% female) completed COST-A and evaluated it. Demographically adjusted norm scores were the difference between expected COST-A scores, based on age, gender, and education, and actual scores. We applied the resulting norm-score formula to two independent cohorts. Results: Participants evaluated COST-A to be of adequate difficulty and duration. Our norm-score formula was shown to be robust: ≈8% of participants in two cognitively normal cohorts had abnormal scores. A cutoff of -1.5 standard deviations proved optimal for distinguishing normal from impaired cognition. Conclusion: With robust norm scores, COST-A is a promising new tool for research and clinical practice, providing low cost and minimally invasive remote assessment of cognitive functioning.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 0604 Genetics, 1109 Neurosciences |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry T Technology > T Technology (General) |
| Divisions: | Sport and Exercise Sciences |
| Publisher: | Wiley Open Access |
| Related URLs: | |
| Date of acceptance: | 1 July 2021 |
| Date of first compliant Open Access: | 3 December 2021 |
| Date Deposited: | 03 Dec 2021 12:24 |
| Last Modified: | 03 Dec 2021 12:30 |
| DOI or ID number: | 10.1002/dad2.12234 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/15863 |
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