Hanstock, HG, Edwards, JP, Roberts, R and Walsh, NP (2018) High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor. Biological Psychology, 133. pp. 85-88. ISSN 0301-0511

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Abstract

Tear secretory immunoglobulin-A (SIgA) is a putative biomarker of common-cold risk with potential utility in non-invasive diagnostics. As SIgA secretion at the ocular surface is under strong autonomic control, we investigated the relationship between HR reactivity and tear SIgA responses to novel experiential stress. Thirty-two healthy participants undertook a 60s zip-line ride to evoke acute stress and a seated-rest control trial in a randomised-crossover design. We recorded heart rate (HR) continuously and collected unstimulated tear samples 5min pre-, 2min post- and 20min post-stress/control. Stress increased HR and state anxiety whereas tear SIgA concentration decreased 44% post-stress vs. CONTROL: Higher peak HR values during stress uniquely explained 21% of the variance in tear SIgA reactivity to stress (p<0.01); high HR reactors displayed greater decreases in tear SIgA concentration. We conclude that physiological arousal increases immune reactivity to acute stress and highlight tear SIgA as a minimally-invasive, physiologically relevant biomarker of immune reactivity.

Item Type:	Article
Uncontrolled Keywords:	1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	Elsevier
Related URLs:	Author
Date Deposited:	15 Feb 2022 12:18
Last Modified:	15 Feb 2022 12:30
DOI or ID number:	10.1016/j.biopsycho.2018.02.002
URI:	https://researchonline.ljmu.ac.uk/id/eprint/16298

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