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The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial

Jones, AW, March, DS, Thatcher, R, Diment, B, Walsh, NP and Davison, G (2017) The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial. European Journal of Nutrition, 58 (1). pp. 335-344. ISSN 1436-6207

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Abstract

BACKGROUND: Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction, but there is a lack of research with clinically relevant in vivo measures. AIM: To investigate the effects of COL supplementation on in vivo immunity following prolonged exercise using experimental contact hypersensitivity (CHS) with the novel antigen diphenylcyclopropenone (DPCP). METHODS: In a double-blind design, 31 men were randomly assigned to COL (20 g/day) or placebo (PLA) for 58 days. Participants ran for 2 h at 60% maximal aerobic capacity on day 28 and received a primary DPCP exposure (sensitisation) 20 min after. On day 56, participants received a low-dose-series DPCP challenge to elicit recall of in vivo immune-specific memory (quantified by skinfold thickness 24 and 48 h later). Analysis of the dose-response curves allowed determination of the minimum dose required to elicit a positive response (i.e., sensitivity). RESULTS: There was no difference in summed skinfold thickness responses between COL and PLA at 24 h (p = 0.124) and 48 h (p = 0.405). However, sensitivity of in vivo immune responsiveness was greater with COL at 24 h (p < 0.001) and 48 h (p = 0.023) with doses ~ twofold greater required to elicit a positive response in PLA. CONCLUSIONS: COL blunts the prolonged exercise-induced decrease in clinically relevant in vivo immune responsiveness to a novel antigen, which may be a mechanism for reduced illness reports observed in the previous studies. These findings also suggest that CHS sensitivity is highly relevant to host defence.

Item Type: Article
Uncontrolled Keywords: 1111 Nutrition and Dietetics
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Springer
Related URLs:
Date Deposited: 15 Feb 2022 12:22
Last Modified: 15 Feb 2022 12:30
DOI or ID number: 10.1007/s00394-017-1597-6
URI: https://researchonline.ljmu.ac.uk/id/eprint/16299
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