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Jones, AW, March, DS, Thatcher, R, Diment, B, Walsh, NP and Davison, G (2017) The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial. European Journal of Nutrition, 58 (1). pp. 335-344. ISSN 1436-6207
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Abstract
BACKGROUND: Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction, but there is a lack of research with clinically relevant in vivo measures. AIM: To investigate the effects of COL supplementation on in vivo immunity following prolonged exercise using experimental contact hypersensitivity (CHS) with the novel antigen diphenylcyclopropenone (DPCP). METHODS: In a double-blind design, 31 men were randomly assigned to COL (20 g/day) or placebo (PLA) for 58 days. Participants ran for 2 h at 60% maximal aerobic capacity on day 28 and received a primary DPCP exposure (sensitisation) 20 min after. On day 56, participants received a low-dose-series DPCP challenge to elicit recall of in vivo immune-specific memory (quantified by skinfold thickness 24 and 48 h later). Analysis of the dose-response curves allowed determination of the minimum dose required to elicit a positive response (i.e., sensitivity). RESULTS: There was no difference in summed skinfold thickness responses between COL and PLA at 24 h (p = 0.124) and 48 h (p = 0.405). However, sensitivity of in vivo immune responsiveness was greater with COL at 24 h (p < 0.001) and 48 h (p = 0.023) with doses ~ twofold greater required to elicit a positive response in PLA. CONCLUSIONS: COL blunts the prolonged exercise-induced decrease in clinically relevant in vivo immune responsiveness to a novel antigen, which may be a mechanism for reduced illness reports observed in the previous studies. These findings also suggest that CHS sensitivity is highly relevant to host defence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1111 Nutrition and Dietetics |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport and Exercise Sciences |
| Publisher: | Springer |
| Related URLs: | |
| Date of acceptance: | 12 December 2017 |
| Date of first compliant Open Access: | 15 February 2022 |
| Date Deposited: | 15 Feb 2022 12:22 |
| Last Modified: | 15 Feb 2022 12:30 |
| DOI or ID number: | 10.1007/s00394-017-1597-6 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16299 |
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