Al-Balushi, MS, Said, EA, Hasson, SS, Al-Busaidi, JZ, Al-Reesi, I, Idris, M, Al-Ghafri, W, Al-Kalbani, M and Al-Jabri, AA (2016) High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery. Iranian Journal of Immunology, 13 (2). pp. 114-123. ISSN 1735-1383

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Abstract

Background: Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the fetus are not completely understood.
Objectives: To investigate the changes of the anti-H. pylori IgM, IgA and IgG levels in healthy Omani pregnant women during pregnancy and 3 months after delivery.
Methods: Serum samples obtained from 70 Omani healthy pregnant women, with no history of autoimmune diseases, were tested for anti-H. pylori IgM, IgA and IgG in the first trimester of pregnancy and 3 months after delivery. In parallel and as a control group, sera obtained from a group of 70 healthy non-pregnant Omani women were tested. The levels of anti-H. pylori IgM, IgA and IgG were measured using standard Enzyme Linked Immunosorbent Assays (ELISAs).
Results: Anti-H. pylori IgA levels were found to be significantly higher during pregnancy (p=0.046) and after delivery (p=0.02) when compared to the control group. Moreover, a significant increase in the levels of anti-H. pylori IgM, IgA and IgG was detected after delivery (p=0.002) when compared to the levels during pregnancy.
Conclusion: Pregnancy is associated with an increase in the levels of anti-H. pylori IgA antibodies. In addition, anti-H. pylori IgM, IgG and IgA antibody levels increase after delivery.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Shiraz University of Medical sciences
Date Deposited:	21 Feb 2022 11:25
Last Modified:	21 Feb 2022 11:25
URI:	https://researchonline.ljmu.ac.uk/id/eprint/16355

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