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Kiel, IA, Jones, H, Lionett, S, Røsbjørgen, R, Lydersen, S, Vanky, E and Moholdt, T (2022) Cardiovascular Health Does Not Change Following High-Intensity Interval Training in Women with Polycystic Ovary Syndrome. Journal of Clinical Medicine, 11 (6). ISSN 2077-0383
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Cardiovascular Health Does Not Change Following High-Intensity Interval Training in Women with Polycystic Ovary Syndrome.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Introduction: polycystic ovary syndrome (PCOS) is associated with cardiovascular disease (CVD) risk factors. First-line therapy for PCOS is lifestyle changes including exercise. We compared CVD risk factors between women with and without PCOS and examined the responses to high-intensity interval training (HIIT). Methods: women with PCOS were randomized to HIIT (n = 41) or a non-exercise control group (n = 23) for 16 weeks. Women without PCOS (n = 15) were age- and BMI-matched to participants with PCOS and completed 16 weeks of HIIT. CVD markers included blood pressure, heart rate, flow-mediated endothelial function (FMD), carotid intima-media thickness (IMT), concentrations of lipids, glucose, insulin, and matrix metalloproteinase-9 (MMP-9). Results: resting heart rate was higher in women with PCOS than without PCOS (p =.011) and was reduced after HIIT in women with PCOS (−2.8 beats/min, 95% CI: −5.4, −0.2, p = 0.037). FMD was not significantly different between women with PCOS (5.5%, SD 4.1) and those without PCOS (8.2%, SD 3.9) at baseline. HIIT reduced time-to-peak dilatation of the brachial artery in women with PCOS compared with women without PCOS (−55 sec, 95% CI: −96, −13 p = 0.012). Conclusions: we found little difference in CVD risk factors between women with and without PCOS at baseline, but some indications of endothelial dysfunction in women with PCOS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1103 Clinical Sciences |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC1200 Sports Medicine R Medicine > RG Gynecology and obstetrics |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | MDPI |
| Date Deposited: | 15 Mar 2022 09:32 |
| Last Modified: | 04 Apr 2022 12:00 |
| DOI or ID number: | 10.3390/jcm11061626 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/16490 |
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