Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

The impact of age, sex, cardio-respiratory fitness and cardiovascular disease risk on dynamic cerebral autoregulation and baroreflex sensitivity

Maxwell, J, Bannell, D, Brislane, A, Carter, S, Miller, GD, Roberts, KA, Hopkins, ND, Low, DA, Carter, H, Thompson, A, Claassen, J, Thijssen, D and Jones, H (2022) The impact of age, sex, cardio-respiratory fitness and cardiovascular disease risk on dynamic cerebral autoregulation and baroreflex sensitivity. European Journal of Applied Physiology. ISSN 1439-6319

[img]
Preview
Text
The impact of age sex cardiorespiratory ftness and cardiovascular disease risk on dynamic cerebral autoregulation and baroreflex sensitivity.pdf - Published Version
Available under License Creative Commons Attribution.

Download (723kB) | Preview

Abstract

Background: Humans display an age-related decline in cerebral blood flow and increase in blood pressure (BP) but changes in the underlying control mechanisms across the lifespan is less well understood. We aimed to; (i) examine the impact of age, sex, cardiovascular disease (CVD) risk and cardio-respiratory fitness on dynamic cerebral autoregulation and cardiac baroreflex sensitivity, and (ii) explore the relationships between dynamic cerebral autoregulation and cardiac baroreflex sensitivity. Methods: 206 participants aged 18-70 years were stratified into age categories. Cerebral blood flow velocity was measured using transcranial Doppler ultrasound, repeated squat stand manoeuvres were performed (0.10 Hz) and transfer function analysis was used to assess dynamic cerebral autoregulation and cardiac baroreflex sensitivity. Multivariable linear regression was used to examine the influence of age, sex, CVD risk and cardio-respiratory fitness on dynamic cerebral autoregulation and cardiac baroreflex sensitivity. Linear models determined the relationship between dynamic cerebral autoregulation and baroreflex sensitivity. Results: Age, sex, CVD risk and cardio-respiratory fitness did not impact dynamic cerebral autoregulation normalised gain, phase or coherence with minimal change in all models (P>0.05). Baroreflex sensitivity gain was attenuated with age when adjusted for sex and CVD risk (young-older; β=-2.86 P<0.001) along with baroreflex sensitivity phase (young-older; β=-0.44, P<0.001). There was no correlation between dynamic cerebral autoregulation normalised gain and phase with either parameter of baroreflex sensitivity. Conclusion: Ageing was associated with a decreased cardiac baroreflex sensitivity but dynamic cerebral autoregulation appears to remained unchanged. Additionally, our data suggests that sex, CVD risk and cardio-respiratory fitness have little effect.

Item Type: Article
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Springer
Date Deposited: 18 Mar 2022 15:08
Last Modified: 26 Apr 2022 08:15
URI: https://researchonline.ljmu.ac.uk/id/eprint/16519
View Item View Item